Gene Variant Detail

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Gene RAD51C
Variant P21A
Impact List missense
Protein Effect no effect
Gene Variant Descriptions RAD51C P21A lies within a region of the Rad51c protein required for Holliday junction resolution activity (UniProt.org). P21A binds to Rad51b, Rad51d, and Xrcc3 to similar levels of wild-type protein in a yeast assay and demonstrates homologous recombination activity similar to wild-type Rad51c in cultured cells (PMID: 36099300).
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C P21A

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Transcript NM_058216.3
gDNA chr17:g.58692704C>G
cDNA c.61C>G
Protein p.P21A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002876.3 chr17:g.58692704C>G c.61C>G p.P21A RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58692704C>G c.61C>G p.P21A RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58692704C>G c.61C>G p.P21A RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58692704C>G c.61C>G p.P21A RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58692704C>G c.61C>G p.P21A RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58692704C>G c.61C>G p.P21A RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58692704C>G c.61C>G p.P21A RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58692704C>G c.61C>G p.P21A RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58692704C>G c.61C>G p.P21A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51C mutant breast cancer not applicable N/A Guideline Risk Factor Germline RAD51C mutations are associated with increased risk of developing breast cancer (NCCN.org). detail...
RAD51C mutant ovarian cancer not applicable N/A Guideline Risk Factor Germline RAD51C mutations are associated with increased risk of developing ovarian cancer (NCCN.org). detail...
RAD51C mutant ovarian serous carcinoma predicted - sensitive Olaparib Case Reports/Case Series Actionable In a clinical case study, Lynparza (olaparib) treatment resulted in a complete response with treatment ongoing at 14 months in a patient with relapsed, metastatic high grade serous ovarian carcinoma harboring RAD51C mutations (PMID: 36176748). 36176748