ERBB4 G741R
Gene Variant Detail

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Gene ERBB4
Variant G741R
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions ERBB4 G741R lies within the protein kinase domain of the Erbb4 protein (UniProt.org). G741R did not show anchorage-independent growth in one cell line in culture but results in increased Erbb4 phosphorylation and IL-3 independent growth in the presence of ligand in culture (PMID: 36860695), and therefore, is predicted to lead to a gain of Erbb4 protein function.
Associated Drug Resistance
Category Variants Paths

ERBB4 mutant ERBB4 act mut ERBB4 G741R

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Transcript NM_005235.3
gDNA chr2:g.211619257C>T
cDNA c.2221G>A
Protein p.G741R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001042599.1 chr2:g.211619257C>T c.2221G>A p.G741R RefSeq GRCh38/hg38
NM_001042599.1 chr2:g.211619257C>T c.2221G>A p.G741R RefSeq GRCh38/hg38
NM_005235.3 chr2:g.211619257C>T c.2221G>A p.G741R RefSeq GRCh38/hg38
XM_017003580.3 chr2:g.211623951C>G c.2221G>C p.G741R RefSeq GRCh38/hg38
NM_005235.2 chr2:g.211619257C>T c.2221G>A p.G741R RefSeq GRCh38/hg38
XM_017003580.2 chr2:g.211623951C>G c.2221G>C p.G741R RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB4 G741R Advanced Solid Tumor sensitive Afatinib Preclinical - Cell culture Actionable In a preclinical study, Gilotrif (afatinib) inhibited growth of a transformed cell line expressing ERBB4 G741R in culture (PMID: 36860695). 36860695
ERBB4 G741R Advanced Solid Tumor sensitive Neratinib Preclinical - Cell culture Actionable In a preclinical study, Nerlynx (neratinib) inhibited growth of a transformed cell line expressing ERBB4 G741R in culture (PMID: 36860695). 36860695
ERBB4 G741R Advanced Solid Tumor sensitive Dacomitinib Preclinical - Cell culture Actionable In a preclinical study, Vizimpro (dacomitinib) inhibited growth of a transformed cell line expressing ERBB4 G741R in culture (PMID: 36860695). 36860695
ERBB4 G741R Advanced Solid Tumor resistant Erlotinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing ERBB4 G741R were resistant to Tarceva (erlotinib) treatment in culture (PMID: 36860695). 36860695