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Therapy Name	Dacomitinib
Synonyms
Therapy Description	Vizimpro (dacomitinib) is a second-generation EGFR inhibitor and pan-HER inhibitor that inhibits HER2 and multiple EGFR subtypes including EGFR T790M, resulting in decreased proliferation and increased apoptosis in EGFR-expressing and HER2-expressing tumor cells (PMID: 22761403, PMID: 18606718). Vizimpro (dacomitinib) is FDA approved for use in patients with metastatic non-small cell lung cancer with EGFR exon 19 deletion or L858R mutation as first-line treatment (FDA.gov).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Dacomitinib	Vizimpro	PF-00299804\|PF299804	EGFR Inhibitor 2nd gen 5 HER inhibitor (Pan) 6	Vizimpro (dacomitinib) is a second-generation EGFR inhibitor and pan-HER inhibitor that inhibits HER2 and multiple EGFR subtypes including EGFR T790M, resulting in decreased proliferation and increased apoptosis in EGFR-expressing and HER2-expressing tumor cells (PMID: 22761403, PMID: 18606718). Vizimpro (dacomitinib) is FDA approved for use in patients with metastatic non-small cell lung cancer with EGFR exon 19 deletion or L858R mutation as first-line treatment (FDA.gov).

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT01112527	Phase II	Dacomitinib	PF-00299804 in Adult Patients With Relapsed/Recurrent Glioblastoma	Completed	USA	0
NCT01465802	Phase II	Dacomitinib Alclometasone Doxycycline	Study Of Dacomitinib (PF-00299804) In Advanced NSCLC Patients (Post Chemo Or Select First Line) To Evaluate Prophylactic Intervention On Derm And GI AEs And PRO	Completed	USA	1
NCT01737008	Phase I	Cisplatin Dacomitinib	Study of Dacomitinib With Radiotherapy With and Without Cisplatin in Patients With Squamous Cell Carcinoma of the Head and Neck	Completed	CAN	0
NCT01858389	Phase II	Dacomitinib	A Study Of Dacomitinib (PF-00299804) In Patients With Advanced Non-Small Cell Lung Cancer	Completed	USA	1
NCT03755102	Phase I	Dacomitinib	A Pilot Study of Dacomitinib With or Without Osimertinib for Patients With Metastatic EGFR Mutant Lung Cancers With Disease Progression on Osimertinib.	Completed	USA	0
NCT02925234	Phase II	Crizotinib Sunitinib Niraparib Olaparib Lorlatinib Erdafitinib Talazoparib Dacomitinib Axitinib Panitumumab	The Drug Rediscovery Protocol (DRUP Trial) (DRUP)	Recruiting	NLD	0
NCT06486142	Phase III	Osimertinib Afatinib Dacomitinib	EGFR-mutated Lung Cancer in Randomized Investigator-Initiated Study (ERIS)	Recruiting	SWE	0
NCT02047747	Phase II	Dacomitinib	A Phase II Study of Dacomitinib in Progressive Brain Metastases	Terminated	USA	0
NCT04811001	Phase II	Dacomitinib Osimertinib	Best EGFR-TKI Sequence in NSCLC Harboring EGFR Mutations (CAPLAND)	Unknown status	ITA	0

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