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Gene RAD51C
Variant G162E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51C G162E does not lie within any known functional domains of the Rad51c protein (UniProt.org). G162E retains binding with Xrcc3 in a yeast assay and rescues survival of Rad51c-null cells in culture, however, results in decreased interaction with Rad51b and Rad51d in a yeast assay and reduced homologous recombination activity compared to wild-type Rad51c in cultured cells (PMID: 36099300), and therefore, its effect on Rad51c protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C G162E

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Transcript NM_058216.3
gDNA chr17:g.58696773G>A
cDNA c.485G>A
Protein p.G162E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_058216.2 chr17:g.58696773G>A c.485G>A p.G162E RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58696773G>A c.485G>A p.G162E RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58696773G>A c.485G>A p.G162E RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58696773G>A c.485G>A p.G162E RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58696773G>A c.485G>A p.G162E RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58696773G>A c.485G>A p.G162E RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58696773G>A c.485G>A p.G162E RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51C G162E Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G162E sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C G162E Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C G162E sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112