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Gene RAD51C
Variant T132I
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RAD51C T132I does not lie within any known functional domains of the Rad51c protein (UniProt.org). T132I results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, and reduced homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C inact mut RAD51C T132I

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Transcript NM_058216.3
gDNA chr17:g.58695180C>T
cDNA c.395C>T
Protein p.T132I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_058216.3 chr17:g.58695180C>T c.395C>T p.T132I RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58695180C>T c.395C>T p.T132I RefSeq GRCh38/hg38
NM_002876.3 chr17:g.58695180C>T c.395C>T p.T132I RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58695180C>T c.395C>T p.T132I RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58695180C>T c.395C>T p.T132I RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58695180C>T c.395C>T p.T132I RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58695180C>T c.395C>T p.T132I RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58695180C>T c.395C>T p.T132I RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58695180C>T c.395C>T p.T132I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51C T132I Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C T132I sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C T132I Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C T132I sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112