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RET D567Y - Gene Variant Detail

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Gene RET
Variant D567Y
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET D567Y lies within the extracellular domain of the Ret protein (UniProt.org). D567Y results in increased phosphorylation of Ret and Erk, IL3-independent growth in culture, and tumor formation in a mouse model (PMID: 36166639).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET D567Y

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Transcript NM_020975.6
gDNA chr10:g.43112903G>T
cDNA c.1699G>T
Protein p.D567Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406744.1 chr10:g.43112903G>T c.1699G>T p.D567Y RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43112903G>T c.1699G>T p.D567Y RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43112903G>T c.1699G>T p.D567Y RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43112903G>T c.1699G>T p.D567Y RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43112903G>T c.1699G>T p.D567Y RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43112903G>T c.1699G>T p.D567Y RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43112903G>T c.1699G>T p.D567Y RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43112903G>T c.1699G>T p.D567Y RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43112903G>T c.1699G>T p.D567Y RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43112903G>T c.1699G>T p.D567Y RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET D567Y Advanced Solid Tumor sensitive Selpercatinib Preclinical - Cell line xenograft Actionable In a preclinical study, Retevmo (selpercatinib) inhibited Ret signaling and viability in transformed cells expressing RET D567Y in culture and inhibited tumor growth in a cell line xenograft model (PMID: 36166639). 36166639
RET D567Y Advanced Solid Tumor sensitive Pralsetinib Preclinical - Cell line xenograft Actionable In a preclinical study, Gavreto (pralsetinib) inhibited Ret signaling and viability in transformed cells expressing RET D567Y in culture and inhibited tumor growth in a cell line xenograft model (PMID: 36166639). 36166639