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RET D584N - Gene Variant Detail

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Gene RET
Variant D584N
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET D584N lies within the extracellular domain of the Ret protein (UniProt.org). D584N confers a gain of function to Ret as demonstrated by increased Erk phosphorylation and IL3-independent growth in culture (PMID: 36166639).
Associated Drug Resistance
Category Variants Paths

RET mutant RET act mut RET D584N

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Transcript NM_020975.6
gDNA chr10:g.43112954G>A
cDNA c.1750G>A
Protein p.D584N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406759.1 chr10:g.43112954G>A c.1750G>A p.D584N RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43112954G>A c.1750G>A p.D584N RefSeq GRCh38/hg38
NM_001406762.1 chr10:g.43113675G>A c.1750G>A p.D584N RefSeq GRCh38/hg38
NM_001406765.1 chr10:g.43112954G>A c.1750G>A p.D584N RefSeq GRCh38/hg38
NM_001406764.1 chr10:g.43113675G>A c.1750G>A p.D584N RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43112954G>A c.1750G>A p.D584N RefSeq GRCh38/hg38
NM_001406761.1 chr10:g.43113675G>A c.1750G>A p.D584N RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43112954G>A c.1750G>A p.D584N RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43112954G>A c.1750G>A p.D584N RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43112954G>A c.1750G>A p.D584N RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43112954G>A c.1750G>A p.D584N RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43112954G>A c.1750G>A p.D584N RefSeq GRCh38/hg38
NM_001406763.1 chr10:g.43112954G>A c.1750G>A p.D584N RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET D584N Advanced Solid Tumor sensitive Selpercatinib Preclinical - Biochemical Actionable In a preclinical study, Retevmo (selpercatinib) inhibited Ret signaling in transformed cells expressing RET D584N in culture (PMID: 36166639). 36166639
RET D584N Advanced Solid Tumor sensitive Pralsetinib Preclinical - Biochemical Actionable In a preclinical study, Gavreto (pralsetinib) inhibited Ret signaling in transformed cells expressing RET D584N in culture (PMID: 36166639). 36166639