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Gene RAD51C
Variant D141G
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51C D141G does not lie within any known functional domains of the Rad51c protein (UniProt.org). D141G results in proficient interaction with Rad51b and Xrcc3 and reduced interaction with Rad51d in a yeast assay (PMID: 36099300), but has not been fully biochemically characterized and therefore, its effect on Rad51c protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C D141G

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Transcript NM_058216.3
gDNA chr17:g.58696710A>G
cDNA c.422A>G
Protein p.D141G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_058216.3 chr17:g.58696710A>G c.422A>G p.D141G RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58696710A>G c.422A>G p.D141G RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58696710A>G c.422A>G p.D141G RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58696710A>G c.422A>G p.D141G RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51C mutant ovarian serous carcinoma predicted - sensitive Olaparib Case Reports/Case Series Actionable In a clinical case study, Lynparza (olaparib) treatment resulted in a complete response with treatment ongoing at 14 months in a patient with relapsed, metastatic high grade serous ovarian carcinoma harboring RAD51C mutations (PMID: 36176748). 36176748
RAD51C mutant breast cancer not applicable N/A Guideline Risk Factor Germline RAD51C mutations are associated with increased risk of developing breast cancer (NCCN.org). detail...
RAD51C mutant ovarian cancer not applicable N/A Guideline Risk Factor Germline RAD51C mutations are associated with increased risk of developing ovarian cancer (NCCN.org). detail...