Gene Variant Detail

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Gene BRAF
Variant N581T
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF N581T lies within the protein kinase domain of the Braf protein (UniProt.org). N581T has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Braf in culture (PMID: 29533785), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF N581X BRAF N581T

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Transcript NM_004333.6
gDNA chr7:g.140753393T>G
cDNA c.1742A>C
Protein p.N581T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378468.1 chr7:g.140753393T>G c.1742A>C p.N581T RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753393T>G c.1742A>C p.N581T RefSeq GRCh38/hg38
NM_004333 chr7:g.140753393T>G c.1742A>C p.N581T RefSeq GRCh38/hg38
XM_005250045 chr7:g.140753393T>G c.1742A>C p.N581T RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753393T>G c.1742A>C p.N581T RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753393T>G c.1742A>C p.N581T RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753393T>G c.1742A>C p.N581T RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753393T>G c.1742A>C p.N581T RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF N581T colorectal cancer not predictive Fluorouracil + Leucovorin + Oxaliplatin + Panitumumab Case Reports/Case Series Actionable In a clinical study, the combination of Vectibix (panitumumab) with FOLFOX as a first-line therapy resulted in a partial response with progression-free survival lasting 1.4 months in a patient with metastatic colorectal cancer harboring BRAF N581T (PMID: 31515458). 31515458