RET A641R
Gene Variant Detail

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Gene RET
Variant A641R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET A641R lies within the transmembrane domain of the Ret protein (UniProt.org). A641R results in decreased self-association in an in vitro assay (PMID: 16732321), but has not been fully biochemically characterized and therefore, its effect on Ret protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RET mutant RET A641R

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Transcript NM_020975.6
gDNA chr10:g.43114521_43114522delGCinsCG
cDNA c.1921_1922delGCinsCG
Protein p.A641R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406744.1 chr10:g.43114521_43114522delGCinsCG c.1921_1922delGCinsCG p.A641R RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114521_43114522delGCinsCG c.1921_1922delGCinsCG p.A641R RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114521_43114522delGCinsCG c.1921_1922delGCinsCG p.A641R RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43114521_43114522delGCinsCG c.1921_1922delGCinsCG p.A641R RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114521_43114522delGCinsCG c.1921_1922delGCinsCG p.A641R RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114521_43114522delGCinsCG c.1921_1922delGCinsCG p.A641R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET A641R medullary thyroid carcinoma predicted - sensitive Selpercatinib Case Reports/Case Series Actionable In a clinical case study, Retevmo (selpercatinib) treatment resulted in a partial response in a patient with metastatic medullary thyroid carcinoma harboring RET A641R (PMID: 40638225). 40638225