RAD51C N71K
Gene Variant Detail

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Gene RAD51C
Variant N71K
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions RAD51C N71K lies within a region of the Rad51c protein required for Holliday junction resolution activity (UniProt.org). N71K retains binding to Rad51d similar to wild-type Rad51c in a yeast assay, and demonstrates functional homology-directed DNA repair activity in culture (PMID: 40670332), and therefore is predicted to have no effect on Rad51c protein function.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C N71K

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Transcript NM_058216.3
gDNA chr17:g.58694998T>G
cDNA c.213T>G
Protein p.N71K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722002.5 chr17:g.58694998T>G c.213T>G p.N71K RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58694998T>G c.213T>G p.N71K RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58694998T>G c.213T>G p.N71K RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58694998T>G c.213T>G p.N71K RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58694998T>G c.213T>G p.N71K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51C mutant breast cancer not applicable N/A Guideline Risk Factor Germline RAD51C mutations are associated with increased risk of developing breast cancer (NCCN.org). detail...
RAD51C mutant ovarian serous carcinoma predicted - sensitive Olaparib Case Reports/Case Series Actionable In a clinical case study, Lynparza (olaparib) treatment resulted in a complete response with treatment ongoing at 14 months in a patient with relapsed, metastatic high grade serous ovarian carcinoma harboring RAD51C mutations (PMID: 36176748). 36176748
RAD51C mutant ovarian cancer not applicable N/A Guideline Risk Factor Germline RAD51C mutations are associated with increased risk of developing ovarian cancer (NCCN.org). detail...