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Gene FLT3
Variant D835del
Impact List deletion
Protein Effect gain of function
Gene Variant Descriptions FLT3 D835del results in the deletion of an amino acid from the activation loop in the protein kinase domain of the Flt3 protein at amino acid 835 (PMID: 25837374). D835del results in constitutive phosphorylation of Flt3 and activation of Stat5, Erk signaling, leading to transformation of cultured cells (PMID: 15256420).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 D835del

FLT3 mutant FLT3 exon20 FLT3 D835del

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Transcript NM_004119.3
gDNA chr13:g.28018503_28018505delATC
cDNA c.2503_2505delGAT
Protein p.D835delD
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011535015.3 chr13:g.28015681_28015683delCCA c.2503_2505delTGG p.W835delW RefSeq GRCh38/hg38
XM_017020486.1 chr13:g.28015189_28015191delTTT c.2504_2506delAAA p.K835delK RefSeq GRCh38/hg38
XM_017020486.2 chr13:g.28015189_28015191delTTT c.2504_2506delAAA p.K835delK RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28018503_28018505delATC c.2503_2505delGAT p.D835delD RefSeq GRCh38/hg38
NM_004119 chr13:g.28018503_28018505delATC c.2503_2505delGAT p.D835delD RefSeq GRCh38/hg38
XM_011535015 chr13:g.28015681_28015683delCCA c.2503_2505delTGG p.W835delW RefSeq GRCh38/hg38
XM_011535015.2 chr13:g.28015681_28015683delCCA c.2503_2505delTGG p.W835delW RefSeq GRCh38/hg38
XM_017020486 chr13:g.28015189_28015191delTTT c.2504_2506delAAA p.K835delK RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28018503_28018505delATC c.2503_2505delGAT p.D835delD RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References