NTRK2 positive
Gene Variant Detail

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Gene NTRK2
Variant positive
Impact List unknown
Protein Effect unknown
Gene Variant Descriptions NTRK2 positive indicates the presence of NTRK2 mRNA and/or protein.
Associated Drug Resistance
Category Variants Paths

NTRK2 positive

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK2 positive pulmonary large cell neuroendocrine carcinoma sensitive AZD7451 Preclinical Actionable In a preclinical study, AZD7451 treatment inhibited proliferation of a lung large-cell neuroendocrine carcinoma cell line expressing Ntrk2 in culture (PMID: 25054037). 25054037
NTRK2 positive neuroblastoma sensitive GNF-4256 Preclinical - Cell line xenograft Actionable In a preclinical study, GNF-4256 treatment inhibited BDNF-induced phosphorylation of Ntrk2 and growth of neuroblastoma cell lines expressing Ntrk2 in culture, and slowed tumor growth in the neuroblastoma cell line xenograft models (PMID: 25394774). 25394774
NTRK2 positive neuroblastoma sensitive GNF-4256 + Irinotecan + Temozolomide Preclinical - Cell line xenograft Actionable In a preclinical study, GNF-4256 worked synergistically with Camptosar (irinotecan) and Temodar (temozolomide), resulting in growth inhibition and an increased event-free survival in cell line xenograft models of neuroblastoma expressing Ntrk2 (PMID: 25394774). 25394774