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| Gene | KEAP1 |
| Variant | inact mut |
| Impact List | unknown |
| Protein Effect | loss of function |
| Gene Variant Descriptions | KEAP1 inact mut indicates that this variant results in a loss of function of the Keap1 protein. However, the specific amino acid change has not been identified. |
| Associated Drug Resistance | |
| Category Variants Paths |
KEAP1 mutant KEAP1 inact mut |
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05039801 | Phase I | Capivasertib + IACS-6274 Bevacizumab + IACS-6274 + Paclitaxel IACS-6274 | IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors | Recruiting | USA | 0 |
| NCT05954312 | Phase I | VVD-130037 Paclitaxel + VVD-130037 Pembrolizumab + VVD-130037 Docetaxel + VVD-130037 | A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-130037 in Participants With Advanced Solid Tumors | Recruiting | USA | ESP | 1 |