BRIP1 S919P
Gene Variant Detail

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Gene BRIP1
Variant S919P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRIP1 S919P lies within the BRCA1-interacting region of the Brip1 protein (UniProt.org). S919P has been identified in the scientific literature (PMID: 29221171, PMID: 38962713, PMID: 28415781), but has not been biochemically characterized and therefore, its effect on Brip1 protein function is unknown (PubMed, Dec 2025).
Associated Drug Resistance
Category Variants Paths

BRIP1 mutant BRIP1 S919P

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Transcript NM_032043.3
gDNA chr17:g.61685986A>G
cDNA c.2755T>C
Protein p.S919P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_032043.3 chr17:g.61685986A>G c.2755T>C p.S919P RefSeq GRCh38/hg38
XM_047436891.1 chr17:g.61685986A>G c.2755T>C p.S919P RefSeq GRCh38/hg38
XM_047436892.1 chr17:g.61685986A>G c.2755T>C p.S919P RefSeq GRCh38/hg38
XM_011525335.4 chr17:g.61685986A>G c.2755T>C p.S919P RefSeq GRCh38/hg38
XM_011525335 chr17:g.61685986A>G c.2755T>C p.S919P RefSeq GRCh38/hg38
NM_032043 chr17:g.61685986A>G c.2755T>C p.S919P RefSeq GRCh38/hg38
NM_032043.2 chr17:g.61685986A>G c.2755T>C p.S919P RefSeq GRCh38/hg38
XM_011525335.3 chr17:g.61685986A>G c.2755T>C p.S919P RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRIP1 mutant ovarian cancer not applicable N/A Guideline Risk Factor Germline BRIP1 mutations are associated with increased risk of developing ovarian cancer (NCCN.org). detail...