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Gene MAP2K1
Variant K57E
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions MAP2K1 K57E lies within the negative regulatory region of the Map2k1 protein (PMID: 24241536). K57E confers a gain of function to Map2k1 as demonstrated by increased activation of downstream Erk1/2 (PMID: 24463458, PMID: 25370473) and increased transformation in cultured cells and increased proliferation in a competition assay (PMID: 36442478), and is associated with Braf inhibitor resistance in cell culture (PMID: 24463458, PMID: 25370473, PMID: 36442478).
Associated Drug Resistance Y
Category Variants Paths

MAP2K1 mutant MAP2K1 act mut MAP2K1 K57E

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Transcript NM_002755.4
gDNA chr15:g.66435115A>G
cDNA c.169A>G
Protein p.K57E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017022411.3 chr15:g.66435115A>G c.169A>G p.K57E RefSeq GRCh38/hg38
NM_002755 chr15:g.66435115A>G c.169A>G p.K57E RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66435115A>G c.169A>G p.K57E RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66435115A>G c.169A>G p.K57E RefSeq GRCh38/hg38
XM_017022411 chr15:g.66435115A>G c.169A>G p.K57E RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66435115A>G c.169A>G p.K57E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 K57E melanoma resistant Dabrafenib Preclinical Actionable In a preclinical study, MAP2K1 (MEK1) K57E mutations restored extracellular signal-regulated kinase (ERK) activation in the presence of Tafinlar (dabrafenib) in cultured melanoma cell lines (PMID: 24463458). 24463458
MAP2K1 K57E Advanced Solid Tumor sensitive Trametinib Preclinical - Cell culture Actionable In a preclinical study, Mekinist (trametinib) inhibited viability of a transformed cell line expressing MAP2K1 K57E in culture (PMID: 36442478). 36442478
MAP2K1 K57E melanoma sensitive Binimetinib + Encorafenib Preclinical - Cell culture Actionable In a preclinical study, the combination of Braftovi (encorafenib) and Mektovi (binimetinib) synergistically inhibited viability of a melanoma cell line harboring BRAF V600E and expressing MAP2K1 K57E in culture (PMID: 36442478). 36442478