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Gene RAD51C
Variant A324T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51C A324T does not lie within any known functional domains of the Rad51c protein (UniProt.org). The functional effect of A324T is conflicting as it demonstrates homologous recombination activity similar to wild-type Rad51c in one cell line but reduced activity in another cell line, results in variable binding to Rad51d and reduced binding to Rad51b but binds to Xrcc3 to similar levels of wild-type protein in yeast assays, and rescues survival in Rad51c-null cells in culture (PMID: 36099300), and therefore, its effect on Rad51c protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C A324T

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Transcript NM_058216.3
gDNA chr17:g.58732488G>A
cDNA c.970G>A
Protein p.A324T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_058216 chr17:g.58732488G>A c.970G>A p.A324T RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58732488G>A c.970G>A p.A324T RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58732488G>A c.970G>A p.A324T RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51C mutant ovarian cancer not applicable N/A Guideline Risk Factor Germline RAD51C mutations are associated with increased risk of developing ovarian cancer (NCCN.org). detail...
RAD51C mutant breast cancer not applicable N/A Guideline Risk Factor Germline RAD51C mutations are associated with increased risk of developing breast cancer (NCCN.org). detail...
RAD51C mutant ovarian serous carcinoma predicted - sensitive Olaparib Case Reports/Case Series Actionable In a clinical case study, Lynparza (olaparib) treatment resulted in a complete response with treatment ongoing at 14 months in a patient with relapsed, metastatic high grade serous ovarian carcinoma harboring RAD51C mutations (PMID: 36176748). 36176748