RAD51C R312W
Gene Variant Detail

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Gene RAD51C
Variant R312W
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RAD51C R312W does not lie within any known functional domains of the Rad51c protein (UniProt.org). R312W retains binding with Rad51b and Xrcc3, however, results in a loss of Rad51c function as indicated by failure to rescue mitomycin C hypersensitivity and cell cycle arrest (PMID: 28829762), defects in homologous recombination repair (PMID: 28829762, PMID: 36099300), and failure to rescue survival in Rad51c-null cells in culture (PMID: 36099300).
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C inact mut RAD51C R312W

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Transcript NM_058216.3
gDNA chr17:g.58724069C>T
cDNA c.934C>T
Protein p.R312W
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.