Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Profile Name | NTRK2 wild-type |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| NTRK2 wild-type | Advanced Solid Tumor | sensitive | AZD6918 | Preclinical | Actionable | In a preclinical study, AZD6918 treatment inhibited Ntrk2 autophosphorylation and BDNF-induced cell proliferation of transformed cell lines expressing wild-type Ntrk2 in culture (PMID: 21242122). | 21242122 |