Molecular Profile Detail

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Profile Name ARID1B dec exp
Gene Variant Detail

ARID1B dec exp (no effect)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ARID1B dec exp Advanced Solid Tumor predicted - sensitive Cisplatin Preclinical - Cell culture Emerging In a preclinical study, siRNA knockdown of ARID1B in cultured tumor cells resulted in increased sensitivity to Platinol (cisplatin), suggesting that tumors with ARID1B loss or inactivation may have increased response to DNA damaging agents (PMID: 24788099). 24788099