Molecular Profile Detail

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Profile Name NTRK1 rearrange
Gene Variant Detail

NTRK1 rearrange (unknown)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK1 rearrange Advanced Solid Tumor predicted - sensitive Entrectinib Clinical Study Actionable In a clinical study, Rozlytrek (entrectinib) treatment resulted in objective response in 75% (3/4) of patients with advanced solid tumors harboring rearrangement in NTRK1, NTRK2, or NTRK3 genes (AACR Apr 2016, Abstract # CT007). detail...
NTRK1 rearrange sarcoma sensitive Entrectinib Guideline Actionable Rozlytrek (entrectinib) is included in guidelines as a standard treatment for patients with advanced sarcomas harboring NTRK rearrangement (PMID: 34303806; ESMO.org). detail... 34303806
NTRK1 rearrange sarcoma sensitive Larotrectinib Guideline Actionable Vitrakvi (larotrectinib) is included in guidelines as a standard treatment for patients with advanced sarcomas harboring NTRK rearrangement (PMID: 34303806; ESMO.org). detail... 34303806
NTRK1 rearrange colon adenocarcinoma predicted - sensitive Larotrectinib Case Reports/Case Series Actionable In a clinical case study, adjuvant Vitrakvi (Larotrectinib) treatment resulted in decrease in the metastases and RECIST stabilization with a progression-free survival of 21 months in a patient with metastatic colon adenocarcinoma harboring an NTRK1 rearrangement who had comorbidities contraindicating the use of chemotherapy (PMID: 41571604). 41571604