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| Profile Name | TP53 - NTRK1 |
| Gene Variant Detail | |
| Relevant Treatment Approaches | Larotrectinib |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| TP53 - NTRK1 | infant-type hemispheric glioma | predicted - sensitive | Larotrectinib | Larotrectinib | Case Reports/Case Series | Actionable | In a clinical case study, Vitrakvi (larotrectinib) treatment resulted in an overall 65.8% size decrease in the enhancing lesions in a pediatric patient with infant-type hemispheric glioma harboring TP53-NTRK1 (PMID: 37666486). | 37666486 |