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| Profile Name | ERBB3 amp |
| Gene Variant Detail | |
| Relevant Treatment Approaches | HER inhibitor (Pan) HER2 (ERBB2) Antibody HER2 (ERBB2) Vaccine HER2 Inhibitor HER3 (ERBB3) Antibody HER3 Inhibitor |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| ERBB3 amp | rectum cancer | sensitive | HER3 (ERBB3) Antibody | AMT-562 | Preclinical - Pdx | Actionable | In a preclinical study, AMT-562 inhibited tumor growth in a patient-derived xenograft (PDX) model of ERBB3 (HER3)-amplified rectal cancer (PMID: 37302522). | 37302522 |