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| Profile Name | KIT S476I |
| Gene Variant Detail | |
| Relevant Treatment Approaches | KIT Inhibitor |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| KIT S476I | mast-cell leukemia | predicted - sensitive | KIT Inhibitor | Midostaurin | Preclinical - Patient cell culture | Actionable | In a preclinical study, treatment with Rydapt (midostaurin) decreased proliferation of patient-derived neoplastic mast cells harboring KIT S476I in culture (PMID: 25209843). | 25209843 |
| KIT S476I | mast-cell leukemia | predicted - sensitive | KIT Inhibitor | Nilotinib | Preclinical - Patient cell culture | Actionable | In a preclinical study, treatment with Tasigna (nilotinib) decreased proliferation of patient-derived neoplastic mast cells harboring KIT S476I in culture (PMID: 25209843). | 25209843 |