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| Profile Name | NTRK1 dec exp NTRK2 dec exp |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| NTRK1 dec exp NTRK2 dec exp | pulmonary large cell neuroendocrine carcinoma | no benefit | AZD7451 | Preclinical | Actionable | In a preclinical study, AZD7451 treatment did not inhibit proliferation of a lung large-cell neuroendocrine carcinoma cell line with reduced Ntrk1 and Ntrk2 expression level in culture (PMID: 25054037). | 25054037 |