Molecular Profile Detail

Case insensitive filtering will display rows if any text in any cell matches the filter term
Use simple literal full or partial string matches
Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
Click on any column header arrows to sort by that column
Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT05997056	Phase II	Nab-rapamycin	Trial of Nab-sirolimus in Patients With Well-differentiated Neuroendocrine Tumors (NETs) of the Gastrointestinal Tract, Lung, or Pancreas Who Have Not Received Prior Treatment With mTOR Inhibitors	Recruiting	USA	0
NCT03213678	Phase II	LY3023414	Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial)	Completed	USA	1
NCT05843253	Phase II	Ribociclib + Temozolomide Everolimus + Ribociclib	Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant	Recruiting	USA \| NLD \| GBR \| DEU \| CAN \| AUS	0
NCT06308419	Phase I	Gemcitabine + Nab-rapamycin	A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions	Active, not recruiting	USA	0
NCT02201212	Phase II	Everolimus	Everolimus for Cancer With TSC1 or TSC2 Mutation	Completed	USA	0
NCT05103358	Phase II	Nab-rapamycin	Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes (PRECISION 1)	Active, not recruiting	USA	2
NCT05997017	Phase II	Nab-rapamycin	Trial of Nab-Sirolimus in Combination With Letrozole in Patients With Advanced or Recurrent Endometrioid Endometrial Cancer	Recruiting	USA	0

Profile Name	TSC1 inact mut
Gene Variant Detail	TSC1 inact mut (loss of function)
Relevant Treatment Approaches	mTOR Inhibitor mTORC1 Inhibitor