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Profile Name | ATR positive |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
ATR positive | breast cancer | predicted - sensitive | VE-821 | Preclinical - Cell culture | Actionable | In a preclinical study, human breast cancer cell lines demonstrated sensitivity to VE-821 in culture, resulting in decreased cell survival (PMID: 25468710). | 25468710 | |
ATR positive | lung cancer | sensitive | Berzosertib + Cisplatin | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, Berzosertib (VX-970) sensitized patient-derived lung cancer cells to Platinol (cisplatin) in culture and in patient-derived xenograft (PDX) models (PMID: 25010037). | 25010037 |