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| Profile Name | CDK12 G909R |
| Gene Variant Detail | |
| Relevant Treatment Approaches | Olaparib |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| CDK12 G909R | prostate cancer | predicted - resistant | Enzalutamide | Preclinical - Cell culture | Actionable | In a preclinical study, expression of CDK12 G909R in prostate cancer cells was associated with increased growth in the presence of Xtandi (enzalutamide) in culture (PMID: 36129942). | 36129942 |