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Profile Treatment Approach Name | Olaparib |
Profile Name | CDK12 G909R |
Drug Class | |
Therapy | Olaparib |
PubMed Id | Reference Title | Details |
---|---|---|
(24554720) | Ovarian cancer-associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors. | Full reference... |
(24240700) | Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity. | Full reference... |
(32343890) | Olaparib for Metastatic Castration-Resistant Prostate Cancer. | Full reference... |