Molecular Profile Detail

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Profile Name MDM2 over exp TP53 wild-type
Gene Variant Detail

MDM2 over exp (no effect)

TP53 wild-type (no effect)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
MDM2 over exp TP53 wild-type neuroblastoma sensitive MX69 Preclinical - Cell culture Actionable In a preclinical study, a neuroblastoma cell line over expressing MDM2 and wild-type for TP53 demonstrated sensitivity to treatment with MX69 in culture, resulting in decreased cell survival (PMID: 27666947). 27666947
MDM2 over exp TP53 wild-type acute lymphoblastic leukemia sensitive MX69 Preclinical - Cell line xenograft Actionable In a preclinical study, MX69 treatment induced cell death and inhibited cell growth in a TP53 wild-type acute lymphocytic leukemia cell line over expressing MDM2, and prolonged survival in xenograft models (PMID: 27666947). 27666947
MDM2 over exp TP53 wild-type osteosarcoma sensitive RO6839921 Preclinical - Cell line xenograft Actionable In a preclinical study, RO6839921 demonstrated anti-tumor activity in TP53 wild-type, MDM2 over-expressing osteosarcoma cell line xenograft models (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr A156). detail...
MDM2 over exp TP53 wild-type acute lymphoblastic leukemia sensitive AQ-101 Preclinical - Cell line xenograft Actionable In a preclinical study, AQ-101 inhibited growth and induced apoptosis in acute lymphocytic leukemia (ALL) cell lines with wild-type TP53 and overexpression of MDM2 in culture, and inhibited development of leukemia in ALL cell line xenograft models (PMID: 29282301). 29282301
MDM2 over exp TP53 wild-type ovarian clear cell carcinoma predicted - sensitive KRT-232 Preclinical - Cell culture Actionable In a preclinical study, KRT-232 (AMG 232) treatment sensitized ovarian clear cell carcinoma cell lines harboring wild-type TP53 and MDM2 overexpression to T-cell mediated killing when co-cultured with T-cells, demonstrating decreased cell viability (PMID: 32655895). 32655895
MDM2 over exp TP53 wild-type ovarian clear cell carcinoma predicted - sensitive KRT-232 + Pembrolizumab Preclinical - Cell culture Actionable In a preclinical study, an ovarian clear cell carcinoma cell line harboring wild-type TP53 and MDM2 overexpression was sensitive to combination treatment with KRT-232 (AMG 232) and Keytruda (pembrolizumab) when co-cultured with T cells, demonstrating increased T-cell mediated cell death (PMID: 32655895). 32655895