Molecular Profile Detail

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
KIT exon11 KIT V654A	gastrointestinal stromal tumor	sensitive	Imatinib + MK2206	Preclinical - Cell culture	Actionable	In a preclinical study, the combination of Gleevec (imatinib) and MK2206 demonstrated synergy in inhibiting growth of a Gleevec (imatinib)-resistant gastrointestinal stromal tumor cell line harboring a KIT exon 11 deletion mutation and KIT V654A in culture (PMID: 27370604).	27370604
KIT exon11 KIT V654A	gastrointestinal stromal tumor	sensitive	Copanlisib	Preclinical - Cell culture	Actionable	In a preclinical study, Aliqopa (copanlisib) inhibited cell growth and PI3K signaling in a gastrointestinal stromal tumor cell line harboring a KIT exon 11 deletion and KIT V654A in culture (PMID: 32371592).	32371592
KIT exon11 KIT V654A	gastrointestinal stromal tumor	predicted - sensitive	Copanlisib + Imatinib	Preclinical - Cell culture	Actionable	In a preclinical study, the combination of Aliqopa (copanlisib) and Gleevec (imatinib) demonstrated enhanced cell growth inhibition but did not result in increased apoptosis of gastrointestinal stromal tumor cells harboring a KIT exon 11 deletion and KIT V654A compared to either agent alone in culture (PMID: 32371592).	32371592

Profile Name	KIT exon11 KIT V654A
Gene Variant Detail	KIT exon11 (unknown) KIT V654A (unknown)
Relevant Treatment Approaches