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Profile Name | APC S811* |
Gene Variant Detail | |
Relevant Treatment Approaches | CTNNB1 Inhibitor Tankyrase Inhibitor |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
APC S811* | colorectal cancer | sensitive | Tankyrase Inhibitor | G007-LK | Preclinical - Cell culture | Actionable | In a preclinical study, treatment with G007-LK decreased active beta-catenin levels and Tcf/LEF activity, and reduced growth of a colorectal cancer cell line harboring APC S811* in culture (PMID: 28179481). | 28179481 |
APC S811* | colorectal cancer | sensitive | Tankyrase Inhibitor | IWR-1 | Preclinical - Cell culture | Actionable | In a preclinical study, treatment with IWR-1 decreased active beta-catenin levels and reduced growth of a colorectal cancer cell line harboring APC S811* in culture (PMID: 28179481). | 28179481 |
APC S811* | colorectal cancer | sensitive | Tankyrase Inhibitor | XAV939 | Preclinical - Cell culture | Actionable | In a preclinical study, XAV939 inhibited growth of a colorectal cancer cell line harboring APC S811* in culture (PMID: 28179481). | 28179481 |
APC S811* | colorectal cancer | sensitive | Tankyrase Inhibitor | STP1002 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, STP1002 inhibited Wnt/beta-catenin signaling and colony formation in colorectal cancer cell lines harboring APC S811* in culture and inhibited tumor growth in a cell line xenograft model (PMID: 35849876). | 35849876 |