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| Profile Name | KIT W557_V559delinsF |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| KIT W557_V559delinsF | gastrointestinal stromal tumor | sensitive | Avapritinib | Preclinical - Pdx | Actionable | In a preclinical study, Ayvakit (avapritinib) treatment resulted in tumor regression in patient-derived xenograft models of gastrointestinal stromal tumor harboring KIT W557_V559delinsF (PMID: 29093181). | 29093181 | |
| KIT W557_V559delinsF | gastrointestinal stromal tumor | sensitive | IDRX-42 | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, IDRX-42 inhibited viability of a gastrointestinal stromal tumor cell line harboring KIT W557_V559delinsF in culture, and induced tumor regression in a patient-derived xenograft (PDX) model (PMID: 40018846). | 40018846 |