Molecular Profile Detail

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Profile Name NRAS K135N
Gene Variant Detail

NRAS K135N (no effect)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
NRAS K135N colorectal cancer predicted - sensitive Cetuximab Preclinical - Cell line xenograft Actionable In a preclinical study, a cell line xenograft model of colorectal cancer expressing NRAS K135N demonstrated similar sensitivity to Erbitux (cetuximab) treatment compared to a NRAS wild-type model (PMID: 34117033). 34117033