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| Profile Name | FLT3 exon 14 ins MERTK pos |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| FLT3 exon 14 ins MERTK pos | acute myeloid leukemia | sensitive | UNC1666 | Preclinical - Patient cell culture | Actionable | In a preclinical study, UNC1666 inhibited Mertk and FLT3 phosphorylation and downstream signaling, induced apoptosis of patient-derived acute myeloid leukemia cell lines harboring FLT3 exon 14 insertions (ITD) in culture (PMID: 25762638). | 25762638 |