Molecular Profile Detail

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Profile Name NTRK2 fusion NTRK2 mut
Gene Variant Detail

NTRK2 fusion (unknown)

NTRK2 mutant (unknown)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK2 fusion NTRK2 mut Advanced Solid Tumor predicted - sensitive Selitrectinib Phase I Actionable In a Phase I trial, Selitrectinib (LOXO-195) treatment resulted in an objective response rate of 45% (9/20) and stable disease in 30% (6/20) of adult and pediatric patients with advanced solid tumors harboring a NTRK mutation associated with resistance to TRK inhibitors in the context of NTRK fusions, who had progressed or were intolerant to prior Trk inhibitors (AACR Annual Meeting 2019, Abstract CT127; NCT03215511). detail...