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Ref Type
PMID
Authors D Hyman, S Kummar, A Farago, B Geoerger, M Mau-Sorensen, M Taylor, E Garralda, R Nagasubramanian, M Natheson, L Song, M Capra, M Jorgensen, A Ho, N Shukla, S Smith, X Huang, B Tuch, N Ku, TW. Laetsch, A Drilon, D Hong
Title Phase I and expanded access experience of LOXO-195 (BAY 2731954), a selective next-generation TRK inhibitor (TRKi)
Journal Vol Issue Date Pages Journal Short Title
AACR Annual Meeting 2019 Online Proceedings
URL https://www.abstractsonline.com/pp8/#!/6812/presentation/9845
Abstract Text AACR Annual Meeting 2019, Abstract CT127

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK2 fusion NTRK2 mut Advanced Solid Tumor predicted - sensitive Selitrectinib Phase I Actionable In a Phase I trial, Selitrectinib (LOXO-195) treatment resulted in an objective response rate of 45% (9/20) and stable disease in 30% (6/20) of adult and pediatric patients with advanced solid tumors harboring a NTRK mutation associated with resistance to TRK inhibitors in the context of NTRK fusions, who had progressed or were intolerant to prior Trk inhibitors (AACR Annual Meeting 2019, Abstract CT127; NCT03215511). detail...
NTRK1 fusion Advanced Solid Tumor predicted - sensitive Selitrectinib Phase I Actionable In a Phase I trial, Selitrectinib (LOXO-195) treatment resulted in an objective response rate of 34% (10/29) and stable disease in 31% (9/29) of adult and pediatric patients with advanced solid tumors harboring NTRK fusions and had progressed or were intolerant to prior Trk inhibitors (AACR Annual Meeting 2019, Abstract CT127; NCT03215511). detail...
NTRK1 fusion NTRK1 mut Advanced Solid Tumor predicted - sensitive Selitrectinib Phase I Actionable In a Phase I trial, Selitrectinib (LOXO-195) treatment resulted in an objective response rate of 45% (9/20) and stable disease in 30% (6/20) of adult and pediatric patients with advanced solid tumors harboring a NTRK mutation associated with resistance to TRK inhibitors in the context of NTRK fusions, who had progressed or were intolerant to prior Trk inhibitors (AACR Annual Meeting 2019, Abstract CT127; NCT03215511). detail...
NTRK2 fusion Advanced Solid Tumor predicted - sensitive Selitrectinib Phase I Actionable In a Phase I trial, Selitrectinib (LOXO-195) treatment resulted in an objective response rate of 34% (10/29) and stable disease in 31% (9/29) of adult and pediatric patients with advanced solid tumors harboring NTRK fusions and had progressed or were intolerant to prior Trk inhibitors (AACR Annual Meeting 2019, Abstract CT127; NCT03215511). detail...