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| Profile Name | KIT V560E |
| Gene Variant Detail | |
| Relevant Treatment Approaches | KIT Inhibitor |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| KIT V560E | gastrointestinal stromal tumor | conflicting | KIT Inhibitor | Imatinib | Case Reports/Case Series | Actionable | In a clinical case study, neoadjuvant Gleevec (imatinib) treatment resulted in decreased tumor size with a maximal response at 12 months in a patient with gastrointestinal stromal tumor (GIST) harboring KIT V560E, allowing for surgical resection (PMID: 34250403). | 34250403 |
| KIT V560E | gastrointestinal stromal tumor | conflicting | KIT Inhibitor | Imatinib | Case Reports/Case Series | Actionable | In a clinical case study, a patient with gastrointestinal stromal tumor harboring KIT V560E was resistant to Gleevec (imatinib) treatment, and in a preclinical study, a patient-derived organoid model was resistant to Gleevec (imatinib) treatment in culture (PMID: 35982969). | 35982969 |
| KIT V560E | gastrointestinal stromal tumor | predicted - sensitive | KIT Inhibitor | Sunitinib | Case Reports/Case Series | Actionable | In a clinical case study, Sutent (sunitinib) treatment resulted in a partial response and symptom improvement in a patient with gastrointestinal stromal tumor harboring KIT V560E, and in a preclinical study, Sutent (sunitinib) treatment decreased viability of the patient-derived organoid in culture (PMID: 35982969). | 35982969 |