Molecular Profile Detail

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Profile Name NTRK2 act mut
Gene Variant Detail

NTRK2 act mut (gain of function)

Relevant Treatment Approaches

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04631744 Phase II Cabozantinib Cabozantinib in Patients With Metastatic Castrate Resistant Prostate Cancer (mCRPC) Terminated USA 0
NCT05435846 Phase I Capmatinib + Trametinib Capmatinib Plus Trametinib for the Treatment of Metastatic Non-small Cell Lung Cancer With MET Exon 14 Skipping Mutation Terminated USA 0
NCT05083481 Phase Ib/II ASP1570 + Pembrolizumab ASP1570 ASP1570 + Trifluridine-tipiracil hydrochloride ASP1570 + Docetaxel ASP1570 + Fluorouracil + Leucovorin + Oxaliplatin ASP1570 + Carboplatin + Pembrolizumab + Pemetrexed Disodium ASP1570 + Fluorouracil + Irinotecan + Leucovorin A Study of ASP1570 Taken by Itself, or ASP1570 Taken Together With Either Pembrolizumab, Standard Therapies, or Both, in Adults With Solid Tumors Terminated USA | FRA | ESP 3
NCT06120075 Phase I AB801 AB801 + Docetaxel AB801 + Docetaxel + Zimberelimab A Study of AB801 Monotherapy and Combination Therapy in Participants With Advanced Malignancies (ARC-27) Active, not recruiting USA 0
NCT03175224 Phase Ib/II Vebreltinib APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors (SPARTA) Recruiting USA | ITA | HUN | GBR | FRA | ESP | CAN | AUS 3
NCT03953235 Phase Ib/II GRT-C903 + GRT-R904 + Ipilimumab + Nivolumab A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens Completed USA 0
NCT05176665 Phase Ib/II EMB-01 EMB-01 in Patients With Advanced/Metastatic Gastrointestinal Cancers Unknown status USA 1
NCT06307795 Phase I ANS014004 A Study to Investigate ANS014004 in Participants With Locally Advanced or Metastatic Solid Tumors Recruiting USA | CAN 1