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Therapy Name Vebreltinib
Synonyms
Therapy Description

Vebreltinib (PLB-1001) is an ATP-competitive, small molecule inhibitor of MET, which is able to permeate the blood brain barrier and may inhibit downstream signaling and block tumor growth (PMID: 30343896).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Vebreltinib Bozitinib|PLB1001|PLB-1001|APL-101|APL 101|APL101 MET Inhibitor 59 Vebreltinib (PLB-1001) is an ATP-competitive, small molecule inhibitor of MET, which is able to permeate the blood brain barrier and may inhibit downstream signaling and block tumor growth (PMID: 30343896).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03175224 Phase Ib/II Vebreltinib APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors (SPARTA) Recruiting USA | ITA | HUN | GBR | FRA | FIN | ESP | CAN | AUS 4


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