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| Profile Name | B2M S14fs B2M LOH |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| B2M S14fs B2M LOH | melanoma | predicted - resistant | Ipilimumab | Case Reports/Case Series | Actionable | In a clinical case study, B2M loss of heterozygosity (LOH) and S14fs were identified as acquired mutations in one lineage of resistant tumor cells in a melanoma patient whose disease progressed on Yervoy (ipilimumab) treatment (PMID: 29070816). | 29070816 |