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Profile Name | MDM2 C464A |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
MDM2 C464A | triple-receptor negative breast cancer | no benefit | YF438 | Preclinical - Cell culture | Actionable | In a preclinical study, YF438 treatment did not inhibit cell growth or induce apoptosis in triple-negative breast cancer cells expressing MDM2 C464A in culture (PMID: 33985974). | 33985974 |