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Profile Name | CD274 pos KIT V560del |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
CD274 pos KIT V560del | gastrointestinal stromal tumor | sensitive | Imatinib + unspecified PD-L1 antibody | Preclinical | Actionable | In a preclinical study, the combination of Gleevec (imatinib) and a PD-L1 antibody resulted in a greater decrease in tumor weight and increased apoptotic activity in a gastrointestinal stromal tumor mouse model harboring KIT V558del (corresponds to human KIT V560del) and expressing PD-L1 compared to Gleevec (imatinib) and control (PMID: 27470968). | 27470968 |