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Profile Name | ABL1 rearrange |
Gene Variant Detail | |
Relevant Treatment Approaches | ABL Inhibitor (pan) |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
ABL1 rearrange | myeloid neoplasm | sensitive | ABL Inhibitor (pan) | Dasatinib | Guideline | Actionable | Sprycel (dasatinib) is included in guidelines as a preferred regimen for patients with a myeloid/lymphoid neoplasm with eosinophilia harboring a ABL1 rearrangement (NCCN.org). | detail... |
ABL1 rearrange | myeloid neoplasm | sensitive | ABL Inhibitor (pan) | Nilotinib | Guideline | Actionable | Tasigna (nilotinib) is included in guidelines as a preferred regimen for patients with a myeloid/lymphoid neoplasm with eosinophilia harboring a ABL1 rearrangement (NCCN.org). | detail... |
ABL1 rearrange | myeloid neoplasm | sensitive | ABL Inhibitor (pan) | Imatinib | Guideline | Actionable | Gleevec (imatinib) is included in guidelines for patients with a myeloid/lymphoid neoplasm with eosinophilia harboring a ABL1 rearrangement (NCCN.org). | detail... |
ABL1 rearrange | myeloid neoplasm | sensitive | ABL Inhibitor (pan) | Bosutinib | Guideline | Actionable | Bosulif (bosutinib) is included in guidelines for patients with a myeloid/lymphoid neoplasm with eosinophilia harboring an ABL1 rearrangement (NCCN.org). | detail... |
ABL1 rearrange | myeloid neoplasm | sensitive | ABL Inhibitor (pan) | Ponatinib | Guideline | Actionable | Iclusig (ponatinib) is included in guidelines for patients with a myeloid/lymphoid neoplasm with eosinophilia harboring an ABL1 rearrangement (NCCN.org). | detail... |
ABL1 rearrange | childhood B-cell acute lymphoblastic leukemia | not applicable | N/A | Guideline | Prognostic | ABL1 rearrangements are associated with a poor prognosis in pediatric patients with B-cell acute lymphoblastic leukemia (NCCN.org). | detail... | |
ABL1 rearrange | B-cell acute lymphoblastic leukemia | not applicable | N/A | Guideline | Prognostic | ABL1 rearrangements are associated with a poor prognosis in patients with B-cell acute lymphoblastic leukemia (NCCN.org). | detail... | |
ABL1 rearrange | myeloid neoplasm | sensitive | Asciminib | Guideline | Actionable | Scemblix (asciminib) is included in guidelines for patients with a myeloid/lymphoid neoplasm with eosinophilia harboring an ABL1 rearrangement (NCCN.org). | detail... |