Molecular Profile Detail

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Molecular Profile	Indication/Tumor Type	Response Type	Relevant Treatment Approaches	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
RET D378_G385delinsE	medullary thyroid carcinoma	predicted - sensitive		Selpercatinib	Case Reports/Case Series	Actionable	In a clinical case study, a pediatric patient with heavily pretreated medullary thyroid cancer harboring RET D378_G385delinsE achieved a partial response after 8 weeks of Retevmo (selpercatinib) treatment, with an 86% reduction in tumor size after 40 weeks, and remained progression-free after 27 months (PMID: 32923911; NCT03157128).	32923911
RET D378_G385delinsE	medullary thyroid carcinoma	predicted - sensitive		Vandetanib	Case Reports/Case Series	Actionable	In a clinical case study, Caprelsa (vandetanib) treatment resulted in an ongoing biochemical response for more than 6 months in a pediatric patient 16 years old with metastatic medullary thyroid carcinoma harboring RET D378_G385delinsE (PMID: 28209747).	28209747

Profile Name	RET D378_G385delinsE
Gene Variant Detail	RET D378_G385delinsE (unknown)
Relevant Treatment Approaches