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Molecular Profile Detail

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Profile Name BRAF class 2
Gene Variant Detail

BRAF class 2 (gain of function)

Relevant Treatment Approaches

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05538130 Phase I PF-07799544 Encorafenib + PF-07799544 PF-07284890 + PF-07799544 PF-07799544 + PF-07799933 A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors Recruiting USA | ISR | CAN 0
NCT05355701 Phase I Binimetinib + PF-07799933 PF-07799933 Cetuximab + PF-07799933 A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations. Recruiting USA | ISR | CAN 0
NCT04916236 Phase I LY3214996 + RMC-4630 Combination Therapy of RMC-4630 and LY3214996 in Metastatic KRAS Mutant Cancers (SHERPA) Terminated NLD 0
NCT05580770 Phase Ib/II BGB3245 + Mirdametinib Mirdametinib + BGB-3245 in Advanced Solid Tumors Terminated USA | AUS 0
NCT06007924 Phase II Defactinib + RO5126766 A Study of Avutometinib and Defactinib in People With Thyroid Cancer Recruiting USA 0
NCT06270082 Phase I IK-595 Study of IK-595 in RAS- or RAF-altered Advanced Tumors Recruiting USA 0
NCT05786924 Phase I BDTX-4933 A Study of BDTX-4933 in Patients With KRAS, BRAF and Select RAS/MAPK Mutation-Positive Cancers Active, not recruiting USA 0
NCT05512208 Phase II Defactinib + RO5126766 A Phase 2 Study of Avutometinib (VS-6766) Plus Defactinib (DURAFAK) Recruiting USA 0
NCT04913285 Phase I Binimetinib + Exarafenib Exarafenib A Study to Evaluate KIN-2787 in Participants with BRAF And/or NRAS Mutation Positive Solid Tumors Recruiting USA | FRA | ESP | AUS 2