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Therapy Name	Binimetinib + PF-07799933
Synonyms
Therapy Description

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Binimetinib	Mektovi	ARRY-162\|ARRY-438162\|MEK162	MEK inhibitor (Pan) 27 MEK1 Inhibitor 27 MEK2 Inhibitor 25	Mektovi (binimetinib) inhibits MEK1 and MEK2 resulting in inhibition of growth factor-mediated signaling and decreased tumor cell proliferation (PMID: 23587417). Mektovi (binimetinib) in combination with Braftovi (encorafenib) is FDA approved for use in patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation (FDA.gov).
PF-07799933		PF07799933\|PF 07799933\|ARRY440\|ARRY 440\|ARRY-440	BRAF Inhibitor 26	PF-07799933 inhibits BRAF mutations, including class 1, 2, and 3 mutations, which potentially leads to decreased downstream Erk signaling and inhibition of tumor growth (PMID: 38691346).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
BRAF del exon2-8 BRAF V600E	papillary thyroid carcinoma	predicted - sensitive	Binimetinib + PF-07799933	Case Reports/Case Series	Actionable	In a Phase I trial, treatment with the combination of PF-07799933 and Mektovi (binimetinib) resulted in a partial response with a tumor reduction of 80% in a patient with papillary thyroid carcinoma harboring BRAF V600E and a deletion of BRAF exons 2-8 (reported as p48 splice variant) (PMID: 38691346; NCT05355701).	38691346
BRAF V600E	high grade glioma	predicted - sensitive	Binimetinib + PF-07799933	Case Reports/Case Series	Actionable	In a Phase I trial, the addition of Mektovi (binimetinib) to treatment with PF-07799933 resulted in a partial response in a patient with high grade glioma harboring BRAF V600E (PMID: 38691346; NCT05355701).	38691346
BRAF V600E	melanoma	predicted - sensitive	Binimetinib + PF-07799933	Case Reports/Case Series	Actionable	In a Phase I trial, treatment with the combination of PF-07799933 and Mektovi (binimetinib) resulted in a partial response in 2 patients with melanoma harboring BRAF V600E and stable disease in 1 patient (PMID: 38691346; NCT05355701).	38691346
BRAF del exon4-8 BRAF V600E	melanoma	sensitive	Binimetinib + PF-07799933	Preclinical - Pdx	Actionable	In a preclinical study, treatment with the combination of PF-07799933 and Mektovi (binimetinib) resulted in tumor regression in a patient-derived xenograft (PDX) model of melanoma harboring BRAF V600E and a BRAF exon 4-8 deletion variant (reported as p61 splice variant) (PMID: 38691346).	38691346

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT05355701	Phase I	Binimetinib + PF-07799933 PF-07799933 Cetuximab + PF-07799933	A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.	Recruiting	USA \| ISR \| CAN	0

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