Molecular Profile Detail

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Profile Name BRAF class 3
Gene Variant Detail

BRAF class 3 (loss of function)

Relevant Treatment Approaches

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05512208 Phase II Defactinib + RO5126766 A Phase 2 Study of Avutometinib (VS-6766) Plus Defactinib (DURAFAK) Recruiting USA 0
NCT04418661 Phase Ib/II Pembrolizumab + RMC-4630 Adagrasib + RMC-4630 Safety and Efficacy Study of SAR442720 in Combination With Other Agents in Advanced Malignancies Terminated USA | NLD | ESP | AUS | ARG 3
NCT04913285 Phase I Binimetinib + Exarafenib Exarafenib A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors Recruiting USA | NLD | FRA | ESP | AUS 3
NCT05786924 Phase I BDTX-4933 A Study of BDTX-4933 in Patients With KRAS, BRAF and Select RAS/MAPK Mutation-Positive Cancers Active, not recruiting USA 0
NCT05355701 Phase I Binimetinib + PF-07799933 PF-07799933 Cetuximab + PF-07799933 A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations. Recruiting USA | ISR | CAN 0
NCT06270082 Phase I IK-595 Study of IK-595 in RAS- or RAF-altered Advanced Tumors Recruiting USA 0
NCT05580770 Phase Ib/II BGB3245 + PD-0325901 Mirdametinib + BGB-3245 in Advanced Solid Tumors Active, not recruiting USA | AUS 0
NCT06007924 Phase II Defactinib + RO5126766 A Study of Avutometinib and Defactinib in People With Thyroid Cancer Recruiting USA 0