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Profile Name | VHL S139fs |
Gene Variant Detail | |
Relevant Treatment Approaches | mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
VHL S139fs | leukemia | resistant | ARV-771 | Preclinical - Cell culture | Actionable | In a preclinical study, a leukemia cell line demonstrated resistance to ARV-771 and was found to have acquired VHL S139fs in culture (PMID: 36329119). | 36329119 |