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| Profile Name | BRAF V487_P492delinsA ERBB3 pos |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| BRAF V487_P492delinsA ERBB3 pos | pancreatic cancer | sensitive | AMT-562 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AMT-562 inhibited growth in a cell line xenograft model of ERBB3 (HER3)-positive pancreatic cancer harboring BRAF V487_P492delinsA (PMID: 37302522). | 37302522 |